A wide range of analytical services are available in many areas of peptide, protein and nucleic acid application areas. Specific skills are described in more detail in analytical ultracentrifugation, calorimetry and peptide synthesis sections accessed by from the above button bar or hypertext links.  A wider range of skills are summarized below;

Protein purification and small (<1 mg) to pilot (>10g) scales;
      - Purification by affinity, ion-exchange, HIC and IMAC 
         chromatography
      - Purification of antibodies by Protein A or G affinity
      - Plasma/serum abundant protein depletion by Blue dye or 
         immunochemical based affinity media
      - Creation of immunoaffinity supports; beads, membranes and
         magnetic particles  
      - Pre-fractionation of complex protein samples, such as plasma
         or serum for Biomarker discovery
      - Preparative purification by isoelectric focusing
      - Protein purification for X-ray crystallography

Contact: purification@analyticalbiotechservices.com

Assay development; 
      -  Protein and nucleic acid conjugation for ELISA detection
          reagents
      -  Development of high sensitivity ELISA assays on plastic and
         membrane solid phases.  Detection by fluorescence, 
         chemiluminescence or autoradioactivity.
      - Biacore SPR analysis

Contact: analysis@analyticalbiotechservices.com

Electrophoresis and Western blotting;
      - 1D and 2DE gel electrophoresis in both native and
          SDS-PAGE formats
      - Coomassie blue and fluorescent staining
      - Western blotting to PVDF and nitrocellulose membranes
      - On membrane staining by immunochemical reagents
      - Glycan staining on Western blots
      - Protein identification following 1D or 2DE gel electrophoresis
          by in-gel
         digest and MALDI-MS mass fingerprint analysis
      - Edman peptide sequencing

Contact: electrophoresis@analyticalbiotechservices.com

Spectroscopy
        - UV/Vis spectroscopy
        - Circular dichroism (CD)
        - Optical rotatory dispersion (ORD)
        - Fluorescence spectroscopy
        - MALDI-ToF mass spectrometry
        - LC-ESI-MS/MS mass spectrometry
        - Low resolution X-ray spectroscopy

Contact: spectroscopy@analyticalbiotechservices.com


Nucleic acids;
      - Oligonucleotide synthesis with 3' and 5' modifications;
          NH2 and fluors
      - PCR, qPCR, TaqMan and design of specific detection probe
         sequences
      -  Sample preparation from a wide range of samples, including
         clinical specimens

Contact: molbiol@analyticalbiotechservices.com

Surface chemistry/materials characterization;
      - Microarray substrates
      - Protein and DNA/RNA binding
      - Peptide binding
      - Surface modification to reduce NSB or filtration "fouling"

Contact: surface@analyticalbiotechservices.com


NOTE:  if the analytical service you require is not listed above please contact analysis@analyticalbiotechservices.com for consultation.  We maintain a network of additional skills and analytical instrumentation in many areas of analytical science in both academic and industrial settings.

For more details on type of service offered and pricing send an email to one of the above contacts outlining type of service requested.  We will get back to you to discus the project and will submit a work proposal or consulting contract for review.  These initial discussions should be restricted to information in the public domain. If required a suitable CDA can be exchanged for these and later discussions.  All work will be carried out in strict confidence and will be recorded in approved hard bound notebooks according to accepted practices required for filing intellectual property in the US and Europe.